Computation through coherence

Benchenane et al [Neuron, 2010, 66, 121] showed that periods of high coherence between prefrontal cortex and hippocampus, predictive of correct choices, corresponds to the reorganization of phase relations between neurons across these structures. Together we are constructing models of the linked hippocampal-cortical microcircuits to show how this spike reorganization arises from interactions between the microcircuits, its control by dopamine, and how coherence ultimately enables effective decision-making. With Sid Wiener (experimental), College de France, and Karim Benchenane (experimental), EPSCI, Paris.